Why We Weaken in Body and Soul as We Age: The Brain's Energy-Saving Strategy

It's all the brain's fault: or more precisely, its energy-saving strategy.

The "Brain-body Energy Conservation" (BEC) model is a new breakthrough theory from the promising interdisciplinary science of mitochondrial psychobiology.

Why we age is more or less understood – general wear and tear of the organism at the cellular level. But why do we increasingly suffer from various unpleasant external signs and functional changes as we age, which we explain with the standard phrase "old age is no joy"?

Why do we need all this, and where do these come from:

  • Increasing fatigue and decreased physical activity?
  • Reduced sensory abilities and detrimental changes in the immune system?
  • And the particularly annoying hormonal "deficits" that hinder a full life?

The Laboratory of Mitochondrial Psychobiology, led by Martin Picard, studies the energy interface between mind, brain, and body, linking molecular processes in cellular power plants - mitochondria - with human experience.

After all, energy is the force that animates the genomic, molecular, and cellular equipment of the brain-body system. Energy flow regulates brain activity and generates human experience. Energy flow maintains our health, being the foundation of our abilities to heal, adapt, and overcome difficulties.

A new preprint on BEC views the brain as a mediator and manager in the body's energy economy. This model describes:

  • Energy costs of cellular aging;
  • How the brain's perception of increased energy consumption is associated with signs of aging;
  • Energy principles explaining how stress factors and gerontological interventions can alter aging trajectories.

Here are the main ideas of the study:

1. The Aging Paradox

Aging is associated with contradictory changes in energy metabolism. At the cellular level, energy consumption increases with age due to the accumulation of molecular damage, but overall energy consumption by the organism decreases.

2. The Role of the Brain

The brain plays a key role in managing energy in the body. As somatic (bodily) tissues become damaged over time, they activate stress responses that require a lot of energy. These damaged cells release signaling molecules (cytokines) that inform the brain about increased energy consumption.

3. The Brain's Energy-Saving Response

To conserve energy, the brain initiates an energy-saving response that determines the external signs and functional changes during aging. This includes fatigue, decreased physical activity, deterioration of sensory abilities, changes in the immune system, and hormonal "deficits".

Thus, this model offers an explanation of how the brain manages the body's energy resources under aging conditions, leading to typical signs of aging and how these processes can be influenced.

The latter means the goal so desired by everyone – how to age without deteriorating and thereby not losing quality of life.

N.B. The previous stage of breakthrough work by the Laboratory of Mitochondrial Psychobiology has already been peer-reviewed and just published. The essence of the study is that our psychosocial experience (e.g., social connections, achieving life goals, loneliness, depression...), through biological processes at the cellular level, affects human health, behavior, and emotional states, and, in general, life expectancy.

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